IMMUNOLOGICAL FEATURES OF HLA-B27 ANTERIOR UVEITIS |
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| Authors: | DENIS WAKEFIELD FRACP FRCPA JOAN EASTER BSc MT PAUL ROBINSON MSC RONALD PENNY DSC FRACP FRCPA |
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| Affiliation: | Department of Immunology, St Vincent's Hospital, Sydney, Department of Medicine. The University of N. S. W. Uveitis Research Clinic Sydney Eye Hospital;Department of Immunology. St Vincent s Hospital. Sydney. Department of Medicine. The University of N. S. W. Uveitis Research Clinic. Sydney Eye Hospital;Department ol Immunology. St Vincent s Hospital. Sydney. Department of Medicine, The University of N. S. W. Uveitis Research Clinic, Sydney Eye Hospital;Department ol Immunology. St Vincent's Hospital Sydney, Department of Medicine. The University of N. S. W. Uveitis Research Clinic, Sydney Eye Hospital |
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| Abstract: | Analysis ol the immunological features of anterior Uveitis (AU) revealed a dichotomy of abnormalities defined in terms of the HLA-B27 status of the patient. HLA-B27-positive AU was characterised by the occurrence of ins autoantibodies and an absolute T cell lymphopenia during active disease which returned to normal with recovery. This phenomenon was not observed in HLA-B27-negative AU or in controls and could not be attributed to antilymphocyte antibodies as these were not detected. Furthermore, there were no changes in T-cell subsets (helper and suppressor T lymphocytes). Compared with HLA-B27-positive AU patients, the HLA-B27-negative group demonstrated elevated lgE levels and increased prevalence of smooth muscle autoantibodies. Key words: anterior Uveitis, HLA-B27, immunological abnormalities, T lymphocytes, autoantibodies. |
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