东莨菪碱和丙泊酚合用对小鼠学习记忆的影响

目的：观察东莨菪碱与丙泊酚合用对小鼠学习记忆的影响。方法：30只小鼠分为3组：东莨菪碱组（S组）、丙泊酚组（P组）、两药合用组（SP组）,每组10只。用跳台法观察小鼠跳台错误次数和跳下潜伏期。结果：SP组用药后第1 d错误次数均多于S组和P组（P〈0.05）,潜伏期均短于S组和P组（P〈0.05）;用药后第2 d和第4 d,各组错误次数、潜伏期的差异均无显著性（P〉0.05）。结论：东莨菪碱与丙泊酚合用当天抑制小鼠学习记忆呈协同作用,学习记忆功能障碍在停药1 d后迅速消失,提示不会造成持久性的学习记忆障碍。

The Effect of Scopolamine and Propofol on Learning and Memory in Mice

Objective：To observe the effect of scopolamine combined with propofol on learning and memory in mice.Methods：30 Kunming Jimpy mice were randomly divided into 3groups： Group S（scopolamine） and group P（propofol）,group SP（scopolamine with propofol）.Step-down test were conducted to evaluate the effects of propofol on learning and memory function in terms of latency period and number of errors made by the mice.Results：On the first day following administration,the latency period of S ＋ P group was shorter than that of S group and P group（P 0.05）,and the number of errors of S ＋ P group was larger than that of S group and P group（P0.05）.However,on the second and fourth day,no significant differences in the number of errors or the latency period among all groups were detected（P0.05）.Conclusions：The combination of scopolamine and propofol can inhibit the learning and memory of mice cooperatively,The disturbance of learning and memory disappears quickly within the 1 st day of drug withdrawal,implying that scopolamine and propofol causes no persistent dysfunction in learning and memory.