西肽普兰与喹硫平联用相关排尿困难和尿潴留

1例69岁女性患者因胸痛入院。入院第2天夜间睡眠差,给予曲唑酮50mg,1次/d睡前服,用药4d症状未改善。停用曲唑酮,改用西酞普兰10mg,每晚睡前口服,但症状仍未见明显改善。诊断为抑郁症,给予西酞普兰20mg,联合喹硫平50mg,每晚睡前口服。服用后出现排尿踌躇、费力,尿量减少。第6天出现排尿困难、尿潴留。停用西酞普兰及喹硫平,行尿道插管。5d后症状缓解,自行排尿。

Difficult urination and urinary retenion related to citalopram combined with quetiapine

A 69-year-old woman was hospitalized for chest pain. On day 2 of admission,the patient had poor sleep at night. She received trazodone 50 mg once daily at bedtime and her symptoms did not improve after 4 days of drug therapy. Trazodone was stopped and changed to citalopram 10 mg at bedtime. But the symptoms did not relieve. Depression was diagnosed and she was given concomitant use of citalopram 20 mg and quetiapine 50 mg at bedtime. She developed urinary hesitancy,straining,and decreased urine volume. On day 6,she experienced difficult urination and urinary retenion. Citalopram and quetiapine were withdrawn and she underwent insertion of an urethral catheter. Five days later,her symptoms improved and spontaneous micturition was restored.