Immunomodulatory Properties of Borage (<Emphasis Type="BoldItalic">Echium amoenum</Emphasis>) on BALB/c Mice Infected with <Emphasis Type="BoldItalic">Leishmania major</Emphasis> |
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Authors: | Nahid Hosseini Mohsen Abolhassani |
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Institution: | (1) Hybridoma Laboratory, Department of Immunology, Pasteur Institute of Iran, Pasteur Ave, Tehran, 13164, Iran;(2) Hybridoma Laboratory, Department of Immunology, Pasteur Institute of Iran, Payam Noor University, Tehran, Iran; |
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Abstract: | Leishmaniasis is caused by parasitic protozoa transmitted by the bite of a female sand fly and is currently endemic in 88
countries. BALB/c mice are highly susceptible to the infection with the parasite Leishmania major, and this susceptibility has been attributed, in part, to the expansion of Th2 cells, production of their cytokines, and
downregulation of Th1 cytokine, interferon gamma (IFN-γ). In this report, we used both aqueous and alcoholic extracts of Iranian
borage (Echium amoenum Fisch & C.A. Mey) for treatment of L. major infection in BALB/c mice. We found that both extracts had immunomodulatory properties and increased the level of IFN-γ and
lowered the parasite burden in the proximal lymph nodes and prevented the necrosis of the footpad as compared with the untreated
infected mice. These results may provide a basis for further studies directed toward the use of the Iranian borage against
L. major infection. |
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