双空白对照头孢匹胺钠与奥硝唑氯化钠配伍实验

目的:建立双空白对照平行实验考察两种药物理化性质方面配伍合理性评价的方法。方法:注射用头孢匹胺钠1．0 g溶于奥硝唑氯化钠注射液100 mL中制得配伍溶液,注射用头孢匹胺钠1．0 g溶于0．9％氯化钠注射液100 mL及奥硝唑氯化钠注射液同为空白对照溶液,于20℃密闭放置0～4 h时,分别对其进行溶液外观、pH值和紫外吸收光谱检查,在波长273、320和357．5 nm处,用紫外分光光计分别测定其中头孢匹胺与奥硝唑含量,所得结果并进行统计学分析。结果:在0～4 h内,溶液外观、pH值和紫外吸收光谱基本不变化;空白对照溶液中所含头孢匹胺钠及奥硝唑的相对百分含量与配伍溶液中所含两药的相对百分含量无显著性差异(P<0．5)。结论:双空白对照平行实验考察注射用头孢匹胺钠在奥硝唑氯化钠注射液中配伍在本次实验范围内是合理的。

Stability Experiments on the Cefpiramide Sodium Combined with Oridazole and Choride Sodium by Double-blank-control

Objective: To establish the double-blank-control parallel experiments to inspect two kinds of medicines physics and chemistry compatibility rationality appraisal method. Methodes: Cefpiramide for injection 1.0 g was dissolved in 100mL oridazole for injection to make the compatibility solution.Cefpiramide for injection was dissolved in 100 mL 0.9% N.S. for injection and oridazole for injection were blank sodium which was placed in closed containers at 20℃in 0-4 h. All the samples were tested for appearance, pH value and th contents using UV spectrophotometry in 273 nm, 320 nm and 357.5 nm . Results: That cefpiramide for injection 1.0 g was dissolved in 100mL oridazole for injection to make the compatibility solution. Cefpiramide for injection was dissolved in 100 mL 0.9% N.S. for injection and oridazole for injection were blank solution which were inplaced in closed containers at 20℃in 0~4 h. All the samples were tested for appearance, pH value and the contents using UV spectrophotometry in 273 nm, 320 nm and 357.5 nm. The results were analyzed by statistically. Conclusions: In 0-4 h, the solution appearance, value pH and UV spectrophotometry had no significant change. The relation presents that in contents in blank-control compared with the compatibility solution there was no significant difference (P<0.5).