Early Resistance to experimental plague in animals immunized with recombinant plague vaccine |
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| Authors: | T. A. Gremyakova V. A. Amel'chenko G. A. Anisimov |
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| Affiliation: | (1) State Research Institute of Applied Microbiology, Obolensk, Moscow Region |
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| Abstract: | The protective properties of recombinantSalmonella minnesota R595/pFS1 strain soon after immunization (1–3 days) are studied in a model of experimental mouse plague. Unlike the commercial EV strainYersinia pestis vaccine produced at the Saratov Anti-Plague Institute (Mikrob Research-Manufacturing Conglomerate), the experimental recombinant p preparation affords a high level of protection from the 1st day postvaccination, and surpasses the commercial preparation in such parameters as LD50, mean survival time, and percentage of survivors. By the 21st day the protective indexes of both preparations are comparable. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny,Vol. 119, N o 1, pp. 54–57, January, 1995 Presented by A. A. Vorob'ev, Member of the Russian Academy of Medical Sciences |
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| Keywords: | vaccine plague capsule antigen recombinant strain Salmonella |
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