Role of proliferation and differentiation of hemopoietic precursors in regeneration of hemopoiesis in cytostatic myelodepressions

Quantitative and qualitative composition of hemopoietic tissue and the intensity of proliferation and differentiation of committed hemopoietic precursors are studied in mice treated with adriamycin, cyclophosphane, or 5-fluorouracil. It is shown that intense maturation of colony-forming units results in rapid regeneration of hemopoiesis even under conditions of reduced proliferation of these cells, whereas inhibition of their differentiation suppresses restoration of bone marrow cellularity despite intense proliferation of hemopoietic precursors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 616–620, December, 1997