| 珍珠梅提取物对化学致癌前病变大鼠抗氧化活力的影响 |
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| 引用本文： | 张学武,孙权,金明,朴春梅,李莲花.珍珠梅提取物对化学致癌前病变大鼠抗氧化活力的影响[J].中西医结合学报,2003,1(1):47-50. |
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| 作者姓名： | 张学武 孙权 金明 朴春梅 李莲花 |
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| 作者单位： | 延边大学医学院生物化学与分子生物学教研室,吉林,延吉,133000 |
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| 摘 要： | 目的 研究珍珠梅乙酸乙酯提取物对二乙基亚硝胺(diethylnitrosamine，DEN)致癌前病变大鼠抗氧化活力的影响。方法 给动物灌胃给药，用DEN制备大鼠化学致癌初期模型。用比色分析法测定大鼠血清、肝匀浆超氧化歧化酶(superoxide dismutase，SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase，GSH—PX)及丙二醛(malondialdehyde，MDA)、谷胱甘肽(glu—tathione，GSH)的含量。结果 珍珠梅乙酸乙酯提取物能显著升高DEN致癌初期大鼠血清、肝匀浆SOD、GSH—PX的活性，升高GSH及降低MDA的含量。结论 珍珠梅乙酸乙酯提取物对DEN致癌前病变大鼠的抗氧化活力有升高作用。
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| 关 键 词： | 珍珠梅 化学致癌作用 大鼠 抗氧化活力 病理学 |
| 文章编号： | 1672-1977(2003)01-0047-04 |
| 修稿时间： | 2003年3月7日 |
Effect of Sorbaria Sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine |
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| ZHANG Xue Wu,SUN Quan,JIN Ming,Piao Chun Mei,Li Lian Hua.Effect of Sorbaria Sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine[J].Journal of Chinese Integrative Medicine,2003,1(1):47-50. |
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| Authors: | ZHANG Xue Wu SUN Quan JIN Ming Piao Chun Mei Li Lian Hua |
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| Institution: | Department of Biochemistry & Molecular Biology, College of Medicine, Yanbian University, Yanji, Jilin Province 133000, China. zlz2913835@sina.com |
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| Abstract: | Objective To study the effect of Sorbaria sorbifolia extract on anti oxidative activities in rats with precancerosis induced by diethylnitrosamine. Methods Sorbaria sorbifolia was perfused into stomach of rats with DEN induced precancerosis, then the biochemical indexes were investigated. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH PX), and the concentrations of malondialdehyde (MDA), glutathione (GSH) were investigated by colorimetric method. Results Sorbaria sorbifolia extract increased SOD, GSH PX and decreased MDA,GSH levels in serum and liver homogenate. Conclusion Sorbaria sorbifolia extract significantly increased anti oxidative activities in rats with precancerosis induced by diethylnitrosamine. |
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| Keywords: | Sorbaria sorbifolia precancerous condition anti oxidative activity |
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