| 人胚胎和兔结膜成纤维细胞对抗肿瘤药物敏感性的比较 |
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| 引用本文： | 李秋明,宋绣雯,陈美兰,牛富文,王英华. 人胚胎和兔结膜成纤维细胞对抗肿瘤药物敏感性的比较[J]. 中华眼底病杂志, 1994, 10(4): 223-225 |
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| 作者姓名： | 李秋明 宋绣雯 陈美兰 牛富文 王英华 |
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| 作者单位： | 河南医科大学第一附属医院眼科 |
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| 摘 要： | 比较了体外培养条件下人胚胎和兔结膜成纤维细胞对5种抗肿瘤药的敏感性。结果表明长春新碱和阿霉素在0.001~10mg/L、5-FU在1~1000mg/L、顺铂在0.01~10mg/L的浓度范围内时，人胚胎结膜成纤维细胞对这几种药物的敏感性显著低于兔结膜成纤维细胞（P＜0.01）；两种细胞对VP-16的敏感性差别不明显（P＞0.05）.提示在进行眼内增殖性疾病防治药物的体外筛选时，用人结膜成纤维细胞较好；将动物实验结果用于临床时，要考虑种属之间的药物敏感性差异。（中华眼底病杂志，1994，10：223-225）
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| 关 键 词： | 结膜，成纤维细胞，抗肿瘤药 |
| 收稿时间： | 1993-11-15 |
| 修稿时间： | 1994-05-18 |
DIFFERENCE IN SENSITIVITIES OF CONJUNCTIVA FIBROBLASTS OF HUMAN EMBRYO AND RABBIT TO ANTINEOPLASTICS |
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| Li Qiuming,Sun Xiuwen,Chen Meilan,et al.. DIFFERENCE IN SENSITIVITIES OF CONJUNCTIVA FIBROBLASTS OF HUMAN EMBRYO AND RABBIT TO ANTINEOPLASTICS[J]. Chinese Journal of Ocular Fundus Diseases, 1994, 10(4): 223-225 |
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| Authors: | Li Qiuming Sun Xiuwen Chen Meilan et al. |
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| Affiliation: | Department of Ophthalmology,First Affiliated Hospital,Henan Medical University,Zhengzhou 450052. |
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| Abstract: | We compared the sensitivities of human embryo conjtmctival fihroblasts(HECF)and rabbit conjunctival fibroblasts(RCF)m five anlineoplasties in vitro.When the concentration of vincrismum and doxorubicin was 0.001~10mg/L.5-FU was 1~1000mg/L and cisplatin was 0.01~10mg/L,the sensitivities of HECF to tile drugs were lower than that of RCF (P<0.01).while the difference of the sensitivilics be;ween HECF and RCF to VP-16 was not significant (P＜0.05). The results suggested that the selection of therapeutic agents for intraocular proliferative disease wilh'hunmn conjunctiva fihroblasts may be more valuable than that with RCF.（Chin J Ocul Fundus Dis,1994,10:223-225） |
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| Keywords: | human rabbit conjunctiva fibroblasts antineoplastics |
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