Antioxidant properties of thiamine |
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| Authors: | P I Lukienko N G Mel'nichenko I V Zverinskii S V Zabrodskaya |
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| Institution: | (1) Laboratory of Biochemical Pharmacology, Institute of Biochemistry, Belarussian Academy of Sciences, Minsk |
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| Abstract: | Thiamine (10−4–10−6 M) inhibits lipid peroxidation in rat liver microsome and free radical oxidation of oleic acidin vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide. The antioxidant
effect of thiamine is probably related to sucessive transfer of 2H+ from the NH2 group of the pyrimidine ring and H+ from the thiazole ring (after its opening) to reactive substrates.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 303–305, September, 2000 |
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| Keywords: | thiamine antioxidants microsomes iron hydroperoxides |
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