急性结膜炎患者治疗前后血清hs-CRP、IL-6、IL-10、IL-18检测的临床意义

目的:探讨了急性结膜炎患者治疗前后血清hs-CRP、IL-6、IL-10、IL-18水平的变化及意义.方法:分别应用放免法、免疫比浊法和酶联法对38例急性结膜炎患者进行了血清hs-CRP、IL-6、IL-10和IL-18水平检测,并与35名正常健康人作比较.结果:急性结膜炎患者在治疗前血清hs-CRP、IL-6、IL-10和IL-18水平均非常显著地高于正常人(P＜0.01),经2周的抗炎治疗后则与正常人比较无显著性差异(P＞0.05).结论:检测急性结膜炎患者血清hs-CRP、IL-6、IL-10和IL-18水平的变化对临床观察预后有重要的临床价值.

Clinical Significance of Determination of Changes in Serum hs-CRP, IL-6,IL-10,and IL-18 Levels After Treatment in Patients with Acute Conjunctivitis

Objective To study the clinical significance of changes of serum hs-CRP, IL-6, IL-10 and IL-18 levels in patients with acute conjunctivitis after treatment. Methods Serum IL-6, IL-10 (with RIA) hs-CRP (with Immuno-turbidity) and IL-18 (with ELISA) levels were measured in 38 patients with acute conjunctivitis both before and after treatment as well as in 35 controls. Results The serum hs-CRP, IL-6, IL-10 and IL-18 levels in the patients before treatment were significantly higher than those in the controls (P<0.01). After 2 weeks of treatment, there were no significant differences between the levels in patients and controls (P>0.05). Conclusion Measurement of the changes of serum hs-CRP, IL-6, IL-10 and IL-18 levels after treatment might be inportant for outcome prediction in patients with acute conjunctivitis.