Antinociceptive effects of Trigonella foenum-graecum leaves extract |
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| Institution: | 1. Department of Pharmacology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran;2. Institute of Biochemistry and Biophysics, Tehran University, P.O. Box 13145-1384, Tehran, Iran;1. Medical Affairs Europe and Australia, Grünenthal, Zieglerstrasse 6,52078 Aachen, Germany;1. Pharmacology of Pain and Neuromodulation Laboratory: Preclinical Researches, Department of Pharmacology, Institute of Basic Health Sciences (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil;2. Animal Experimentation Unit and Graduate Research Group, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035-003, Brazil;3. Graduate Program in Biological Sciences: Physiology, ICBS, UFRGS, Porto Alegre, RS 90050-170, Brazil;4. Graduate Program in Biological Sciences: Pharmacology and Therapeutics, ICBS, UFRGS, Porto Alegre, 90050-170, Brazil;5. Postgraduate Program in Health and Human Development, Unilasalle University Centre, Canoas, RS, 92010-000, Brazil;1. Laboratório de Farmacologia da Dor e Neuromodulação: Investigações Pré-Clínicas, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;2. Programa de Pós-Graduaç?o em Medicina: Ciências Médicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;3. Unidade de Experimentação Animal e Grupo de Pesquisa e Pós-Graduação, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;4. Centro Universitário FADERGS, Porto Alegre, RS, Brazil, Health and Wellness School Laureate International Universities;5. Universidade Federal do Pampa, Avenida Antônio Trilha, 1847, 97300-000, São Gabriel, RS, Brazil;1. CPQBA, University of Campinas, P.O. Box 6171, 13083-970 Campinas, SP, Brazil;2. GEQOB, ICEx, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil;3. UIC, University of Illinois at Chicago, 3320 MBRB, MC 865 Chicago, IL, USA;4. FCF, University of Campinas, P.O. Box 6029, 13083-859 Campinas, SP, Brazil |
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| Abstract: | There are some reports concerning the antinociceptive effects of the plant Trigonella foenum-graecum (TFG) in Iranian traditional medicine. Because of the side effects of nonsteroidal anti-inflammatory and antinociceptive drugs, and in search for more potent and less harmful compounds, we tried to study the antinocicptive effects of TFG leaves by using tail-flick and formalin tests. Intraperitoneal (i.p.) administration of 500 mg/kg of TFG extract and 100 and 300 mg/kg of sodium salicylate (SS), as a positive control, did not show any effect in the tail-flick test, but the 1000 and 2000 mg/kg of the extract produced significant increase in the tail-flick latency. SS (300 mg/kg, i.p.) induced antinociception in the second phase of the formalin test. TFG (500 mg/kg, i.p.) demonstrated antinociception only in the first phase, but 1000 and 2000 mg/kg, i.p. doses alleviated the pain in both phases. Preliminary LD50 of the extract was very close to 4000 mg/kg, i.p. We conclude that: (1) the extract of TFG leaves produces antinociceptive effects through central and peripheral mechanisms; (2) the antinociceptive effects of 2000 mg/kg of the extract was more potent than 300 mg/kg of SS. |
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