性激素与原发性肝癌

运用ＲＩＡ法对７６例男性肝癌及１０例女性肝癌患者血清睾丸酮（Ｔ）、雌二醇（Ｅ２）及孕酮（Ｐ）水平进行测定。结果：男性肝癌手术组及非手术组血清Ｔ水平显著高于肝良性病变组及正常对照组，Ｅ２水平则显著低于后两组；雄／雌激素比例（Ｔ／Ｅ２）显著高于后两组；肝癌切除后Ｔ水平下降，Ｅ２水平升高，Ｔ／Ｅ２比值下降，与肝良性病变组及正常对照组比较无显著差异。女性肝癌组Ｔ、Ｅ２水平与肝良性病变组及正常对照组比较无显著差异，但Ｔ／Ｅ２比例明显高于正常对照组。男、女肝癌组的Ｐ水平均未见明显改变。本组资料结果提示：高Ｔ水平及低Ｅ２水平与肝癌有关，性激素比例失调在肝癌的发生和发展中起了重要作用

SEX HORMONE AND PRIMARY LIVER CANCER

The serum level of testosterone (T), estradiol (E 2) and progesterone (P) in 86 cases with primary liver cancer (PLC) (male:76 cases; female:10 cases) was determined by RIA method. The result showed that for male cases, serum level of T and ratio of T/E 2 in operation group and nonoperation group was significantly higher than that in benign hepatic diseases group (BHD group) and normal control group (NC group), but the value of E 2 obviously lower than the later two groups. After tumor resection, the level of E 2 increased, while serum level of T and value of T/E 2 decreased, which had no significant difference as contrasted with BHD group and NC group. The serum level of T,E 2 in female PLC group made no difference to BHD group and NC group, but the value of T/E 2 much higher than NC group. No obvious changes of the serum level of progesterone can be observed in both male and female cases. Our research showed that high serum testosterone level and low estradiol level may be concerned with PLC. The possibility and importance of sex hormone imbalance on initializing and developing of PLC is suggested.