贝母甲素联合抗生素抑制多重抗生素耐药菌的实验研究 |
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引用本文: | 王嵩,孙颖立,胡凯文.贝母甲素联合抗生素抑制多重抗生素耐药菌的实验研究[J].中国中西医结合杂志,2003(Z1). |
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作者姓名: | 王嵩 孙颖立 胡凯文 |
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作者单位: | [1]广州市花都区中医院内二科 [2]广州市花都区中医院内二科 广州510800) [3]广州510800) |
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摘 要: | 目的:了解贝母甲素联合抗生素抑制多重抗生素耐药菌的作用并探讨其机制。方法:(1)用试管法测定贝母甲素与抗生素联合抑菌作用;(2)采用流式细胞仪分析贝母甲素对受试菌株内柔红霉素浓度的影响。结果:(1)贝母甲素联合抗生素,对铜绿假单胞菌普遍具有抑制作用;(2)贝母甲素联合优立新、青霉素对受试菌株抑菌效果明显优于与其他类抗生素联合;(3)经贝母甲素处理的耐药菌,菌体内荧光强度高于未经贝母甲素处理株。结论:贝母甲素与抗生素合用具有协同增效作用,量效关系尚待进一步研究。
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关 键 词: | 耐药性 细菌 生物碱 贝母甲素 |
Experimental Study of Peimine Combined with Antibiotics in Inhibiting Multiple Antibiotics Resistant Bacteria Strain |
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Authors: | WANG Song SUN Ying-li HU Kai-wen |
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Institution: | Huadu District TCM Hospital; Guangzhou(510800); |
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Abstract: | Objective:To study the effect of Peimine combined with antibiotics in inhibiting multiple antibiotics resistant bacteria strain and ex- plore its mechanisms.Methods:(1) Using test tube method to determine Peimine combined with antibiotics to inhibit the multiple antibiotics resistant bacteria strain;(2) The effect of Peimine on concentration of daunorubicin in tested bacteria strains was analyzed with flow cytome- try.Results:(1) Peimine combined with antibiotics has inhibitory effect on pseudomonas viriden... |
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Keywords: | drug resistance bacteria alkaloid Peimine |
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