| Studies on the Relationship between Production of Oxygen Free Radicals and Cardiac Failure of Coronary Artery Disease |
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| 作者姓名： | Chen Lihua~ Zhang Yimin~ Bai Buyun~ Zhu Miaozhang~ Zhao Baolu~ Hou Jingwu~ Xin Wenjuan~ |
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| 作者单位： | ~1 Department of Physiology，Fourth Military Medical University，Xi'an; ~2 Institute of Biophysics，Academia Sinica，Beijing; ~3 Department of Cardiovascular Disease，514 hospital，Beijing |
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| 摘 要： | <正> In this paper, the relationship between Oxygen Free Radicals（OFR） and cardiac failure of Coronary Artery Disease（CAD）was studied. The authors analyse the release of OFR, as measured by Lumin-dependent chemiluminescence, from the polymorphonuclear leukocytes（PMN）; the activity of plasma superoxide dismutase （SOD） and the concentration of malondialdehyde（MDA）in patients of CAD with heart failure. The results showed that compared with the health controls and the group of CAD without heart failure, the release of OFR in respiratory burst of the PMN stimulated with PMA（phorbol myristate acetate）and the concentration of MDA in plasma were significantly increased（p<0.05） and the activity of SOD was markedly lower（p<0.05）in the group of CAD with heart failure.It suggests that the enhanced production of OFR by PMN, the increased concen tration MDA in plasma and the decreased SOD might be associated with the genesis and development of cardiac failure, The use of agents that reduce the amount of OFR would be of value in the prevention and treatment of cardiac failure.
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Studies on the Relationship between Production of Oxygen Free Radicals and Cardiac Failure of Coronary Artery Disease |
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| Chen Lihua,Zhang Yimin,Bai Buyun,Zhu Miaozhang,Zhao Baolu,Hou Jingwu,Xin Wenjuan.Studies on the Relationship between Production of Oxygen Free Radicals and Cardiac Failure of Coronary Artery Disease[J].Chinese Heart Journal,1991,0(2). |
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| Authors: | Chen Lihua Zhang Yimin Bai Buyun Zhu Miaozhang Zhao Baolu Hou Jingwu Xin Wenjuan |
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| Institution: | Chen Lihua~1,Zhang Yimin~1,Bai Buyun~3,Zhu Miaozhang~1,Zhao Baolu~2,Hou Jingwu~2,Xin Wenjuan~2 |
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| Abstract: | In this paper, the relationship between Oxygen Free Radicals(OFR) and cardiac failure of Coronary Artery Disease(CAD)was studied. The authors analyse the release of OFR, as measured by Lumin-dependent chemiluminescence, from the polymorphonuclear leukocytes(PMN); the activity of plasma superoxide dismutase (SOD) and the concentration of malondialdehyde(MDA)in patients of CAD with heart failure. The results showed that compared with the health controls and the group of CAD without heart failure, the release of OFR in respiratory burst of the PMN stimulated with PMA(phorbol myristate acetate)and the concentration of MDA in plasma were significantly increased(p<0.05) and the activity of SOD was markedly lower(p<0.05)in the group of CAD with heart failure. It suggests that the enhanced production of OFR by PMN, the increased concen tration MDA in plasma and the decreased SOD might be associated with the genesis and development of cardiac failure, The use of agents that reduce the amount of OFR would be of value in the prevention and treatment of cardiac failure. |
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| Keywords: | free radicals Oxygen Superoxide dismutase Malondialdehyde Heart failure congestive |
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