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Relapsing Wegner's granulomatosis: Successful treatment with cyclosporin-A
Authors:Dr. C. Georganas  D. Ioakimidis  C. Iatrou  B. Vidalaki  K. Iliadou  P. Athanassiou  T. Kontomerkos
Affiliation:(1) From the Department of Rheumatology, District General Hospital of Athens, Athens, Greece;(2) From the Department of Nephrology, District General Hospital of Athens, Athens, Greece;(3) Rheumatology Unit, Department of Medicine, Hammersmith Hospital, London, UK
Abstract:Summary We describe the case of a 32-year-old splenectomised man with severe Wegener's granulomatosis which was refractory to conventional treatment with oral cyclophosphamide and prednisolone. Remission was temporarily induced only with plasma exchange or IV immunoglobulin. Because of frequent relapses of the disease and cyclophosphamide side effects, he was started on treatment with cyclosporin-A and a long lasting remission was achieved.
Keywords:Wegener's Granulomatosis  Vasculitis  Treatment  Cyclophosphamide  Cyclosporin-A  Plasma Exchange  Immunoglobulin
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