白介素-1受体拮抗剂对豚鼠变应性鼻炎的治疗作用

目的：明确白介素-1受体拮抗剂对变应性鼻炎的治疗作用。方法：采用甲苯-2,4-二异氰酸酯（TDI toluene-2,4-diisocyanate)致敏豚鼠,制作变应性鼻炎模型,观察给予白介素-1受体拮抗剂（IL-1ra）处理前后症状和体征的变化,用组织病理学方法观察鼻粘膜的改变,测量鼻粘膜中组胺、血中IgE的含量。结果：用IL-1ra治疗后,变应性鼻炎症状和体征明显改善,HE染色显示,鼻粘膜水肿及炎性细胞浸润,随IL-1ra浓度的提高而改善,鼻粘膜中组胺、血中IgE的含量下降,随白介素-1拮抗剂浓度升高而下降。特别是高剂量组,各指标好于其它各治疗组,阳性对照组也有鼻粘膜水肿,及炎性细胞浸润。结论：局部使用IL-1ra拮抗剂能治疗变应性鼻炎。

Therapeutic effects of interleukin-1 receptor antagonist on allergic rhinitis of guinea pig

AIM: To determine the effect of interleukin-1 receptor antagonist (IL-lra) on allergic rhinitis. METHODS:Allergic rhinitis was induced by toluene-2,4-diisocyanate (TDI). At the end of the treatment, the pathological changes in the nasal mucosa were observed. The concentrations of hitamine in the nasal mucosa and IgE in the blood were determined as well. RESULT: Symptoms of allergic rhinitis were remarkably relieved after IL-lra treatment.Hematoxylin and eosin staining demonstrated that less edema was found in the nasal mucosa and small vessel was normal after IL-lra application, but edema,vasodilation, and inflammatory cell infiltration were discovered in the model group. The concentrations of hitamine in the nasal mucosa and IgE in the blood were less than those in the control group. CONCLUSION: IL-lra im administration selectively and non-traumaticly alleviated nasal congestion, rhinorrhea, and sneezing.