| 聚(油酸/亚油酸-癸二酸)-庆大霉素的体外释药和抑菌活性(英文) |
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| 引用本文： | Yang XF,Zeng FD,Zhou ZB,Huang KX,Xu HB. 聚(油酸/亚油酸-癸二酸)-庆大霉素的体外释药和抑菌活性(英文)[J]. Acta pharmacologica Sinica, 2003, 24(4): 306-310 |
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| 作者姓名： | Yang XF Zeng FD Zhou ZB Huang KX Xu HB |
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| 作者单位： | 华中科技大学同济医学院临床药理教研室,华中科技大学生命科学院化学系,华中科技大学生命科学院化学系,华中科技大学生命科学院化学系 武汉 430030,武汉 430074 中国,武汉 430074 中国,武汉 430074 中国 |
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| 基金项目： | Project Supported by the Natural Science Foundation of Wuhan City, № 996005122G |
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| 摘 要： | AIM：To investigate whether poly(oleic/linoleic acid dimer:sebacic acid)-getamicin[Poly(OAD/LOAD:SA)-gentamicin]delivery system was useful to treat chronic osteomyelitis.METHODS:Drug delivery system consisted of gentamicin sufate dispersed in a copolymer containing oleic/linoleic acid dimer(OAD/LOAD)and sebacic acid(SA)in a 1:1 weight ration.The gentamicin releast from[Poly(OAD/LOAD:SA)-gentamicin]was tested in water 0.9% saline,and phosphate buffer 0.1mol/L,RESULTS:The gentamicin concentration peak was found on d2,then slowly decreased.considerable amout of gentamicin was still released on d 50.From d 2 o d 50,the gentamicin concentration in the releasing fluids was from 59 to 42128-fold and 1.8 to 1314-fold of the MIC for Staphylococcus aureus and Escherichia coli,respectively.Staphylococcus aureus and Escherichia coli were strongly inhibited by the releasing fluids for 50d.The gentamicin release and anti-bacterial activity in the three media were similar.only in 0.1mol/L phosphate buffer,from d 2 to 14 it was lower.CONCLUSION:Poly(OAD/LOAD:SA)-gentamicin was useful to treat chronic osteomyelitis.
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| 关 键 词： | 庆大霉素 药物载体 油酸-亚油酸 癸二酸 多聚体 金黄色葡萄球菌 大肠杆菌 |
In vitro release and antibacterial activity of poly (oleic/linoleic acid dimer: sebacic acid)-gentamicin |
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| Yang Xiu-Fen,Zeng Fan-Dian,Zhou Zhi-Bin,Huang Kai-Xun,Xu Hui-Bi. In vitro release and antibacterial activity of poly (oleic/linoleic acid dimer: sebacic acid)-gentamicin[J]. Acta pharmacologica Sinica, 2003, 24(4): 306-310 |
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| Authors: | Yang Xiu-Fen Zeng Fan-Dian Zhou Zhi-Bin Huang Kai-Xun Xu Hui-Bi |
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| Affiliation: | Department of Clinical Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. xiufenyang@163.net |
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| Abstract: | AIM: To investigate whether poly (oleic/linoleic acid dimer: sebacic acid)-getamicin [Poly(OAD/LOAD:SA)-gentamicin] delivery system was useful to treat chronic osteomyelitis. METHODS: Drug delivery system consisted of gentamicin sufate dispersed in a copolymer containing oleic/linoleic acid dimer (OAD/LOAD) and sebacic acid (SA) in a 1:1 weight ratio. The gentamicin release from [Poly(OAD/LOAD:SA)-gentamicin] was tested in water, 0.9% saline, and phosphate buffer 0.1 mol/L. RESULTS: The gentamicin concentration peak was found on d 2, then slowly decreased, considerable amount of gentamicin was still released on d 50. From d 2 to d 50, the gentamicin concentration in the releasing fluids was from 59 to 42128-fold and 1.8 to 1314-fold of the MIC for Staphylococcus aureus and Escherichia coli, respectively. Staphylococcus aureus and Escherichia coli were strongly inhibited by the releasing fluids for 50 d. The gentamicin release and anti-bacterial activity in the three media were similar, only in 0.1 mol/L phosphate buffer, from d 2 to d 14 it was lower. CONCLUSION: Poly(OAD/LOAD: SA)-gentamicin was useful to treat chronic osteomyelitis. |
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| Keywords: | drug delivery systems polymers gentamicins drug carriers Staphylococcus aureus Escherichia coli osteomyelitis |
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