| 亚低温对大鼠外伤性脑损伤保护作用的实验研究 |
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| 引用本文： | 江素君,袁红,郑婷,倪有娣,裘五四.亚低温对大鼠外伤性脑损伤保护作用的实验研究[J].杭州医学高等专科学校学报,2008,28(3):145-147. |
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| 作者姓名： | 江素君 袁红 郑婷 倪有娣 裘五四 |
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| 作者单位： | [1]杭州师范大学医学实验中心,浙江杭州310036 [2]杭州师范大学临床医学院,浙江杭州310036 |
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| 基金项目： | 抗州市医药卫生科技计划项目 |
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| 摘 要： | 目的研究亚低温对大鼠外伤性脑损伤急性期的保护作用。方法27只大鼠随机分为假手术组、亚低温组和常温对照组。采用改进的Feeney自由落体法制作重型外伤性颅脑损伤模型,体表降温法在伤后30 min内达到亚低温目标,检测三组大鼠脑组织的病理变化、含水量以及神经功能缺陷评分。结果亚低温组大鼠脑组织在治疗后24 h的含水量较对照常温组显著降低（P〈0.05）;病理组织学检查见亚低温组大鼠脑损伤较常温组改善;亚低温组大鼠在6 h的神经功能缺陷评分显著低于常温组（P〈0.05）。结论亚低温具有减轻大鼠外伤性颅脑损伤急性期脑水肿及神经功能缺陷的作用。
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| 关 键 词： | 亚低温 脑损伤 外伤性 脑水肿 神经功能缺陷 大鼠 |
Protective effects of mild hypothermia on traumatic brain injury in rats |
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| JIANG Su-jun,YUAN Hong,ZHENG Ting,NI You-di,QIU Wu-si.Protective effects of mild hypothermia on traumatic brain injury in rats[J].Journal of Hangzhou Medical College,2008,28(3):145-147. |
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| Authors: | JIANG Su-jun YUAN Hong ZHENG Ting NI You-di QIU Wu-si |
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| Institution: | JIANG Su-jun1,YUAN Hong1,ZHENG Ting2,NI You-di2,QIU Wu-si2(1.Medical Experimental Center of Hangzhou Normal University,Hangzhou,Zhejiang 310036,China,2.Clinical Medical College,Hangzhou Normal University,China) |
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| Abstract: | Objective To study the protective effects of mild hypothermia against traumatic brain injury of the acute phase in rats. Methods Twenty-seven Sprague-Dawley rats were randomly divided into sham-operation group,mild hypothermia group and normal temperature group.Feeney's model was used to produce severe traumatic brain injury and therapeutic hypothermia was achieved within 30 minutes after injury by surface cooling.The histopathological changes,brain tissue water content and neurological functional deficit s... |
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| Keywords: | mild hypothermia brain injury traumatic cerebral edema neurological functional deficit scales rat |
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