|
|||||
|
|
Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives |
|
| Authors: | Seikwan Oh Soyong Jang Donghyun Kim Inn-Oc Han Jae-Chul Jung |
| Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University 38677-1848, USA. |
| Abstract: | A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia. |
| Keywords: | Benzylideneacetophenones Synthesis Grignard reaction NO generation Free-radical scavenging Cytotoxicity Anti-excitotoxicity |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |