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Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives
Authors:Seikwan Oh  Soyong Jang  Donghyun Kim  Inn-Oc Han  Jae-Chul Jung
Affiliation:Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University 38677-1848, USA.
Abstract:A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.
Keywords:Benzylideneacetophenones  Synthesis  Grignard reaction  NO generation  Free-radical scavenging  Cytotoxicity  Anti-excitotoxicity
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