| Gal-3和Bcl-2蛋白的表达与垂体腺瘤侵袭性的关系 |
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| 引用本文： | 刘志雄,侯永宏,黄垂学,刘运生,傅春燕. Gal-3和Bcl-2蛋白的表达与垂体腺瘤侵袭性的关系[J]. 中国耳鼻咽喉颅底外科杂志, 2006, 12(6): 422-425 |
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| 作者姓名： | 刘志雄 侯永宏 黄垂学 刘运生 傅春燕 |
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| 作者单位： | 1. 中南大学湘雅医院 神经外科 湖南 长沙 410008
2. 中南大学湘雅医院 病理科,湖南 长沙 410008 |
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| 摘 要： | 目的探讨半乳糖凝集素-3(Gal-3)和细胞淋巴瘤/白血病基因-2(Bcl-2)蛋白水平的表达与垂体腺瘤侵袭性的关系。方法采用免疫组化S-P法检测31例非侵袭性和47例侵袭性垂体腺瘤组织中Gal-3和Bcl-2的蛋白表达。结果侵袭性垂体腺瘤组的Gal-3和Bcl-2的蛋白表达均较非侵袭性腺瘤组显著增高(P<0.01)。侵袭性腺瘤组中Gal-3和Bcl-2的表达水平成正相关(P<0.01)。结论侵袭性垂体腺瘤的生物学行为与Gal-3和Bcl-2的表达增高有相关性。Gal-3和Bcl-2在抗凋亡过程中可能存在着内在联系。
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| 关 键 词： | 垂体腺瘤 Gal-3 Bcl-2 侵袭性 凋亡 |
| 文章编号： | 1007-1520（2006）06-0422-04 |
| 收稿时间： | 2006-11-30 |
Expressions of Gal-3 and Bcl-2 and their relationship with the invasiveness in pituitary adenomas |
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| LIU Zhi-xiong, HOU Yong-hong, HUANG Chui-xue, et al. Expressions of Gal-3 and Bcl-2 and their relationship with the invasiveness in pituitary adenomas[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery, 2006, 12(6): 422-425 |
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| Authors: | LIU Zhi-xiong HOU Yong-hong HUANG Chui-xue et al |
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| Abstract: | Objective To detect the expressions of Gal-3 and Bcl-2 in pituitary tumors and explore the relationship between the expressions of Gal-3 and Bcl-2 and the invasiveness of pituitary adenomas.Methods The expressions of Gal-3 and Bcl-2 were detected in 31 non-invasive pituitary adenomas and 47 invasive pituitary adenomas by using immunohistochemical S-P assay.The correlation between the expressions of Gal-3,Bcl-2 and tumor invasiveness were studied.Results Compared with the non-invasive pituitary adenomas,the expressions of Gal-3 and Bcl-2 increased in invasive ones(P<(0.01)).There was a positive correlation between Gal-3 and Bcl-2 at protein level.Conclusion The increased expressions of Gal-3,Bcl-2 are significantly correlated with the invasiveness of pituitary adenomas,and they may play an ingenerate role in the invasiveness and the apoptosis of this tumor. |
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| Keywords: | Pituitary adenoma Gal-3 Bcl-2 Invasiveness Apoptosis |
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