| t(8;21)急性髓性白血病预后分析 |
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| 引用本文： | 孟小莉. t(8;21)急性髓性白血病预后分析[J]. 郑州大学学报(医学版), 2004, 39(2): 304-305 |
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| 作者姓名： | 孟小莉 |
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| 作者单位： | 郑州大学第一附属医院血液科,郑州,450052 |
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| 摘 要： | 目的:研究伴t(8;21)的急性髓性白血病(AML)患者近期疗效。方法:30例伴t(8;21)的AML患者中M01例、M226例、M52例、CML-BPI例。26例伴有t(8;21)的M2患者中简单核型异常9例,复杂核型异常17例,取28例正常核型的M2患者为对照,观察染色体核型异常与化疗后完全缓解(CR)率的关系。结果:t(8;21)的非M2患者除1例M5经治疗为CR外,余3例均为NR;t(8;21)的M2患者的CR率(84.6％(22/26))高于正常核型的M2患者(64.3％(18/28))(P>0.05);简单核型异常的M2/t(8;21)患者化疗CR率(94.1％(16/17))高于伴复杂核型异常的M2/t(8;21)患者(66.7％(6/9))(P>0.05)。结论:t(8;21)的M2患者预后较好。而伴复杂核型M2/1(8;21)患者疗效相对较差。
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| 关 键 词： | t(8,21) 白血病 髓性 急性 疗效 |
| 修稿时间： | 2003-03-06 |
Outcome of t( 8 ;21 )-positive acute myeloid leukemia |
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| MENG Xiaoli. Outcome of t( 8 ;21 )-positive acute myeloid leukemia[J]. Journal of Zhengzhou University: Med Sci, 2004, 39(2): 304-305 |
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| Authors: | MENG Xiaoli |
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| Affiliation: | MENG XiaoliDepartment of Hematology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Aim: To elucidate the therapeutic effect of acute myeloid leukemia (AML) with t(8;21). Method: Karyo-types of 30 patients with AML were analyzed with the R-banding techniques. Results: Of the AML patients with t(8;21) , 84% (26/30) was M2 subtype. The complete remission (CR) rate in the group of M2 with t(8;21) was higher than that in the group of M2 with normal karyotypes (84. 6% (22/26) vs 64. 3% (18/28) ). The CR rate was higher in the group of simple karyotype than that in the group of complicated karyotypes (94. 1% (16/17) vs 66.7% (3/9)). Conclusions: The patients with M2/t(8;21) will survive longer. M2/t(8;21) with complicated karyotypes may prognose poor therapeutic effect. |
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| Keywords: | t(8 21 ) leukemia myeloid acute therapeutic effect |
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