原发性肺癌刀豆凝集素受体分布的观察

经手术切除的134例原发性肺癌组织,用刀豆凝集素-辣根过氧化物酶(ConA-HRP)定位技术观察刀豆凝集素(ConA)受体的分布。癌细胞内ConA受体可见于核膜、质膜及细胞质内,其分布与组织学类型有关,鳞癌核膜上ConA受体阳性反应高于腺癌,而腺癌细胞质内ConA受体高于鳞癌。组织学分级与鳞癌质膜ConA受体呈负相关(P<0.01),而腺癌与细胞质内受体分布呈正相关(P<0.05),未分化癌主要见于核膜上。未发现ConA受体的分布与患者预后之间有联系。

THE DISTRIBUTION OF CONCANAVALIN A RECEPTORS IN PRIMARY CARCINOMA OF LUNG

The nature and distribution of Concanavalin A receptors were studiedin 134 patients with primary carcinoma of the lung by ConA-HRP histo-chemical locating technique. The results showed that ConA receptorswere located on the nuclear membranes, the plasma membranes and in thecytoplasm, and the amount and distribution were related to the histopath-ological pattern. In squamous cell. carcinoma, the ConA receptors of thenuclear membranes were more obvious than in adenocarcinoma, but theintraplasma receptors were more obvious in adenocarcinoma than in squa-mous carcinoma. The distribution of ConA of the plasma membranes insquamous carcinoma was inversely correlated with the histopathologicalgrading (P<0.01), while in adenocarcinoma the correlation was positivefor intraplasma receptors (P<0.05). In the undifferentiated carcinomathe receptors were mainly located on the nuclear membranes. We have notfound any relationship between the prognosis of the patients and the dis-tribution of ConA receptors.