ABO血型与糖尿病发生风险的meta分析

目的 用meta分析方法研究ABO血型在糖尿病患者和健康人群中的分布情况,以评价ABO血型系统与糖尿病发生风险的关系.方法 通过检索PubMed、中国生物医学文献数据库、维普中文科技期刊数据库、中国知网期刊数据库和万方数据库等,收集有关糖尿病与ABO血型系统之间关系的原始文献,按照纳入与排除标准筛选出符合要求的文献并提取出相关的数据,使用NOS量表对纳入文献进行质量评价,采用Review Manager 5.1和Stata 12.0软件进行meta分析.结果 B血型和AB血型在糖尿病患者和对照人群中的分布差异有统计学意义,表现为B血型在糖尿病患者中所占比例高于对照人群(OR=1.13,95％CI:1.05～1.21,P=0.000 7),AB血型则在对照人群中更为常见(OR=0.86,95％CI:0.77～0.97,P=0.01);但亚组分析时发现B血型和AB血型的分布差异仅在国外人群中有统计学意义(P＜0.05).而A血型(OR=0.90,95％CI:0.76～1.07,P=0.24)和O血型(OR=1.00,95％CL0.89～1.13,P=0.96)在两组中的分布差异无统计学意义.结论 糖尿病的发生可能与ABO血型有关.国外人群中B血型的糖尿病发病风险高于其他血型,AB血型可能是糖尿病发生的保护因子,而A血型和O血型在国内外人群中与糖尿病的发生均无关.

ABO blood group and risk of diabetes mellitus: a meta analysis

Objective To evaluate the relationship between ABO blood group system and diabetes mellitus via studying the distribution of ABO blood group in patients with diabetes mellitus and healthy people by meta analysis. Methods We searched PubMed, CBM, VIP, CNKI and Wanfang Databases to collect study about diabetes and ABO blood group system. Eligible studies were selected and the relevant data was extracted according to inclusion criteria , The Newcastle-Ottawa scale(NOS) was used to assess the quality of the included studies,and meta-analysis was performed with the use of stata12.0 software. Results There were differences in distribution of blood group B and blood group AB between diabetic patients and control population, Patients with diabetes had the higher proportion of blood group B than the control group (OR = 1.14,95% CI = 1.06~1.22,p=0.000), on the contrary, blood group AB was more common in healthy people (OR = 0.86,95% CI = 0.77~0.97,p=0.014), but subgroup analysis showed the presence of distribution of blood group B and AB in the case and control groups in the domestic and foreign populations. No difference was observed in the blood group A (OR = 0.92,95% CI = 0.77~1.09,p=0.318) and blood group O (OR = 1.00,95% CI = 0.89~1.13,p=0.955) distributed in both groups. Conclusion In the foreign population, the risk of diabetes in blood group B is higher than others, blood group AB is the protective factor for diabetes.however, blood group A and blood group O are not associated with the occurrence of diabetes in people at home and abroad.