Y-maze learning in two strains of mice. Effects of instrumental and pharmacologic sleep deprivation] |
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Authors: | K Kitahama J L Valatx M Jouvet |
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Affiliation: | Départment de Médecine Expérimentale, UniversitéClaude Bernard, 8, Avenue Rockefeller, F-69373 Lyon Cedex 2 France |
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Abstract: | Effects of instrumental and pharmacological deprivation of sleep on Y-maze learning have been studied in two inbred strains of mice (C57BR/cd/Orl and C57BL/6/Orl), having identical sleep rhythms, but mainly differing in their ability to learn. Administration of alpha-methyl-DOPA (100 mg/kg) provokes complete suppression of paradoxical sleep (PS) for 9-11 h. Injection immediately after each training session over the first 5 days caused a delay in acquisition of an active avoidance task in C57BR mice. Treated C57BL/6 mice exhibited a significant facilitation of acquisition. Similar results were obtained by instrumental deprivation of sleep for 10 h. |
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