| PCNA和Ki-67在非小细胞肺癌组织中的表达及其临床意义 |
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| 引用本文： | 李英杰,于长海,李捷,刘颖,杨毅. PCNA和Ki-67在非小细胞肺癌组织中的表达及其临床意义[J]. 临床军医杂志, 2011, 39(2): 261-263. DOI: 10.3969/j.issn.1671-3826.2011.02.21 |
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| 作者姓名： | 李英杰 于长海 李捷 刘颖 杨毅 |
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| 作者单位： | 解放军总医院第一附属医院,胸心外科,北京,100048 |
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| 摘 要： | 目的探讨PCNA和ki-67在非小细胞肺癌中的表达及意义。方法收集临床手术切除的非小细胞肺癌组织蜡块128例及正常肺组织32例,应用免疫组化检测组织中PCNA和Ki-67的表达,结合临床病理资料和随访资料进行回顾性研究。结果发现非小细胞肺癌组织中PCNA的表达和Ki-67表达均明显高于正常肺组织(P<0.01)。PCNA表达增高与肿瘤病理分级、分期增加以及淋巴结转移之间有相关性(P<0.01),但与肿瘤组织学分型无相关性(P>0.05)。PCNA表达与Ki-67表达之间呈显著正相关(P<0.01)。结论 PCNA及Ki-67高表达是影响患者预后的主要因素,两者的异常表达与肺癌的发生、发展及转移关系密切,对判断肺癌恶性程度及预后有重要参考价值。
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| 关 键 词： | 肺癌 PCNA Ki-67 免疫组化 |
A study on the relationship between expression of KI-67,PCNA and metastasis and prognosis in patients with non-small cell lung carcinoma |
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| Li Ying-jie,Yu Chang-hai,Li Jie,Liu Ying,Yang Yi. A study on the relationship between expression of KI-67,PCNA and metastasis and prognosis in patients with non-small cell lung carcinoma[J]. Clinical Journal of Medical Officer, 2011, 39(2): 261-263. DOI: 10.3969/j.issn.1671-3826.2011.02.21 |
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| Authors: | Li Ying-jie Yu Chang-hai Li Jie Liu Ying Yang Yi |
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| Affiliation: | Li Ying-jie,Yu Chang-hai,Li Jie,Liu Ying,Yang Yi(Department of Thoracic-cardio Surgery,Affiliated Hospital of PLA General Hospital,Beijing 100048,China) |
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| Abstract: | Objective To study the relationship between expression of Ki-67,PCNA and metastasis and prognosis in patients with non-small cell lung cancer.Methods The expression of Ki-67 and PCNA were examined with immunohistochemical technique in 128 specimens of NSCLC and 32 normal neighboring lung tissues.Results The expression of Ki-67 and PCNA in NSCLC tissues was significantly higher than that in benign pulmonary lesion.The results showed that the expression of Ki-67 and PCNA might be helpful for predicting progno... |
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| Keywords: | PCNA Ki-67 |
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