6523例大学新生乙型肝炎病毒和丙氨酸氨基转移酶检测结果分析

目的了解大学新生乙型肝炎(下称乙肝)病毒(HBV)感染与丙氨酸氨基转移酶(ALT)异常情况。方法使用酶联免疫吸附试验(ELISA)检测HBsAg,抗-HBs、HBsAg阳性者进一步用ELISA检测乙肝5项,同时利用全自动生化分析仪检测血清ALT。结果 HBsAg阳性率为6.4%,抗-HBs阳性率为58.7%,HBV全阴率为35%,ALT在HBsAg阴性新生中异常率为3.7%,ALT在HBsAg阳性新生中异常率13.7%。结论 HBV感染与ALT异常密切相关,ALT明显异常者为乙肝活动期,对大学学生应加强传染病相关知识宣传,继续加强乙肝疫苗接种,预防HBV传播。

Detection results analysis of hepatitis B virus and alanine transaminase in 6523 university freshmen

Objective To understand the infection status of hepatitis B virus（HBV）and abnormalities of alanine transaminase（ALT）.Methods To detect HBsAg and anti-HBs by enzyme-linked immunosorbent assay（ELISA）.The subjects with positive HBsAg were further detected 5 indexes of hepatitis B by ELISA.Meanwhile,the automatic biochemical analyzer was used to detect serum ALT.Results The HBsAg positive rate was 6.4%.Anti-HBs positive rate was 58.7%.The full negative rate of HBV was 35%.The ALT abnormality was 3.7% in the HBsAg-negative freshmen and13.7% in the HBsAg-positive freshmen.Conclusion HBV infection is closely related with abnormal ALT.Significant ALT abnormality indicates the activity period of hepatitis B.The knowledge propaganda related to infectious diseases should be strengthened on the university students.The hepatitis B vaccine inoculation should be continuously strengthened for preventing HBV spreading.