硝苯地平防治早产的临床观察

目的　研究用钙通道阻滞剂硝苯地平抑制宫缩、防治早产的临床效果及其副作用。方法　将 84例先兆早产患者随机分为 3组 ,每组 2 8例。A组给予硝苯地平 10 m g,B组给予硝苯地平 2 0 m g,C组为同期未用药对照组。观察推迟分娩时间 ,推迟分娩效果与宫颈开大情况及孕周的关系 ,妊娠结局等。结果　硝苯地平能有效抑制子宫收缩 ,延长孕周 ,从用药两组可看出 ,其抑制强度与剂量相关 ,且在宫颈尚未开大之前 ,越早治疗 ,效果越好 ,本组病例中尚未发现其对母体及胎儿有明显毒副作用。结论　硝苯地平防治早产效果好 ,值得临床上进一步观察应用

Clinical Observations on the Prevention and Treatment of Premature Labor with Nifedipine

Objective To study the effect of a calcium channel antagonist-Nifedipine(NIF) on the prevention and treatment of premature labor, the suppression of uterine contraction, the prolongation of pregnancy, and to observe the side effects of NIF. Methods Eighty-four patients with threatened premature labor were randomly divided into three groups according to the dosage of NIF. Group A received NIF according to a 10 mg dosing schedule; Group B received NIF according to a 20 mg dosing schedule; Group C(not treated with NiF) served as control. The time of delivery delayed, the relationship of therapeutic effect with cervical dilatation and gestational age, and the results of delivery were observed and analyzed. Results In this study, INF effectively suppressed uterine contraction and delayed the time of delivery. The suppressant intensity was associated with the dosage. The therapeutic effects was apparently more noticeable when the treatment was initiated before the active opening of cervical os. No side effect of NIF was observed in Groups A and B.Conclusion Nifedipine is highly effective as a tocolytic agent for the management of premature delivery. It is of clinical usefulness, and the results of the above observations merit further study.