| 藿香正气微乳与藿香正气水的急性毒性与药效比较研究 |
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| 引用本文： | 路艳丽,彭博,贺蓉,高杰,杨华,易红,李建荣.藿香正气微乳与藿香正气水的急性毒性与药效比较研究[J].中国中药杂志,2010,35(15):2004-2007. |
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| 作者姓名： | 路艳丽 彭博 贺蓉 高杰 杨华 易红 李建荣 |
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| 作者单位： | 中国中医科学院,中药研究所,北京,100700 |
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| 基金项目： | 国家"十一五"科技支撑计划(2006BAI09B08-15);国家自然科学基金项目(30472195);"重大新药创制"科技重大专项(2009ZX09301-005-05) |
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| 摘 要： | 目的:比较藿香正气微乳与藿香正气水2种剂型的急性毒性反应及主要药效学指标。方法:以最大给药量试验比较藿香正气微乳与藿香正气水对小鼠的急性毒性反应;采用番泻叶诱导小鼠腹泻模型,以腹泻指数、胃泌素、胃动素为指标,以ED50值为标准,比较2种剂型的止泻作用强度。结果:藿香正气水对小鼠的急性毒性明显高于藿香正气微乳;藿香正气微乳与藿香正气水的ED50值相近。结论:藿香正气微乳的安全性明显高于藿香正气水;藿香正气微乳对番泻叶腹泻模型小鼠的止泻作用与藿香正气水基本相当。
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| 关 键 词： | 藿香正气微乳 藿香正气水 小鼠腹泻模型 腹泻指数 胃泌素 胃动素 |
| 收稿时间： | 2009/12/24 0:00:00 |
Comparative study on acute toxicity and pharmacological effect of Huoxiang Zhengqi microemulsion and Huoxiang Zhengqi tincture |
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| LU Yanli,PENG Bo,HE Rong,GAO Jie,YANG Hu,YI Hong and LI Jiangrong.Comparative study on acute toxicity and pharmacological effect of Huoxiang Zhengqi microemulsion and Huoxiang Zhengqi tincture[J].China Journal of Chinese Materia Medica,2010,35(15):2004-2007. |
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| Authors: | LU Yanli PENG Bo HE Rong GAO Jie YANG Hu YI Hong and LI Jiangrong |
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| Institution: | Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine, Beijing 100700, China;Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine, Beijing 100700, China;Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine, Beijing 100700, China;Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine, Beijing 100700, China;Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine, Beijing 100700, China;Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine, Beijing 100700, China;Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine, Beijing 100700, China |
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| Abstract: | |
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| Keywords: | Huoxiang Zhengqi microemulsion Huoxiang Zhengqi tincture mice diarrhea model diarrhea index gastrin motilin |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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