硼替佐米治疗多发性骨髓瘤的初步临床研究

  目的 初步观察硼替佐米（商品名：万珂）联合化疗对多发性骨髓瘤（MM）的疗效和毒副作用。方法 5例MM患者采用万珂联合地塞米松或DVD方案治疗4个疗程，评价疗效和毒副作用。结果 3例完全缓解（CR），1例部分缓解（PR），1例达到微小反应（MR）；总缓解（CR+PR）率为80 %；最常见的毒副反应为指趾麻木感、轻度白细胞和血小板减少以及肝功能异常改变。结论 万珂联合化疗治疗MM疗效好，毒副作用轻微，患者易于耐受。

The primary clinical study on treatment with velcade for multiple myeloma

Objective To explore the outcome and side-effects in patients with multiple myeloma treated with velcade and combined chemotherapy. Methods 5 patients with multiple myeloma were treated with the combination of velcade and dexamethasone or DVD (V-DVD regimen) chemotherapy. Results 5 patients responded to treatment. Three patients achieved complete remission (CR), 1 achieved partial remission (PR) and 1 achieved micro responded (MR). Major toxicities consisted of peripheral neuropathy, thrombocytopenia and hepatic impairment. Conclusion Velcade combined combination chemotherapy is an effective and safety treatment for patients with multiple myeloma. <