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LC-MSn比较分析三种传统中草药中绿原酸及其衍生物组分
引用本文:王征.LC-MSn比较分析三种传统中草药中绿原酸及其衍生物组分[J].药学学报,2008,43(2):185-190.
作者姓名:王征
作者单位:1. 湖南农业大学,生物科学技术学院,湖南,长沙,410128
2. 英国萨里大学,生物医学与分子科学学院,食品营养与安全研究中心,吉尔福德,萨里郡,CU2 7XH
基金项目:Scholarship for Stabilizing Tablent from Hunan Agricultural University (05WD11),Scholarslip for Excellent Youthfrom Hunan Education Department (07B035)
摘    要:利用LC-MSn分析了杜仲叶、金银花叶以及鱼腥草叶甲醇提取物中绿原酸及其异构体和衍生物。发现3种样品中都含有3种单咖啡酰奎尼酸(绿原酸), 分别是3-咖啡酰奎尼酸(3-caffeoylquinic acid,3-CQA)、 4-CQA和5-CQA。杜仲叶和金银花叶中5-CQA为主要成分,但鱼腥草叶中以3-CQA和4-CQA为主要成分。在杜仲叶中首次发现咖啡酰奎尼酸糖苷;另外还发现金银花叶中有少量5-阿魏酰奎尼酸(5-feruloylquinic acid,5-FQA);鱼腥草叶含有少量的3-FQA和4-肉桂酰奎尼酸(4-p-coumaroylquinic acid,4-pCoQA)。本文首次报道鱼腥草叶中绿原酸异构体成分,为3-CQA和4-CQA的开发提供了来源(植物中绿原酸的结构一般以5-CQA为主)。

关 键 词:杜仲  金银花  鱼腥草  LC-MSn  咖啡酰奎尼酸  阿魏酰奎尼酸  肉桂酰奎尼酸  咖啡酰奎尼酸糖苷
文章编号:0513-4870(2008)02-0185-06
收稿时间:2007-07-03
修稿时间:2007年7月3日

Comparison of the profiles of chlorogenic acids and their derivatives from three Chinese traditional herbs by LC-MSn
WANG Zheng,CLIFFORD Michael N..Comparison of the profiles of chlorogenic acids and their derivatives from three Chinese traditional herbs by LC-MSn[J].Acta Pharmaceutica Sinica,2008,43(2):185-190.
Authors:WANG Zheng  CLIFFORD Michael N
Institution:College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China. wz8918@163.com
Abstract:To investigate the chlorogenic acids resources in Eucommia ulmoides Olive leaves, Lonicera japonica Thunb. leaves and Houttuynla cordata Thunb. leaves, methanolic extracts of these three materials have been analysed qualitatively for chlorogenic acids and their derivatives by structure-diagnostic LC-MS~n. Three monocaffeoylquinic acids (3-CQA, 4-CQA, 5-CQA) were detected. 5-CQA dominated this subgroup in Eucommia ulmoides Olive and Lonicera japonica Thunb. leaves, but 3-CQA and 4-CQA dominated this subgroup of chlorogenic acids in the leaves of Houttuynla cordata Thunb. Caffeoylquinic acid-glycosides were detected for the first time from Eucommia ulmoides leaves. 5-FQA was found in Lonicera japonica Thunb. leaves, and 3-FQA and 4-pCoQA have been identified in Houttuynla cordata Thunb. This is the first report of the chlorogenic acid profile in Houttuynla cordata Thunb. The comparatively unusual profile of caffeoylquinic acids in Houttuynla cordata Thunb. makes it a convenient source of 3-CQA and 4-CQA that are not commercially available.
Keywords:Eucommia ulmoides  Lonicera japonica  Houttuynla cordata  LC-MS~n  caffeoylquinic acids  feruloylquinic acids  p-coumaroylquinic acids  caffeoylquinic acid-glycosides
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