| Immunohistochemical localization of nitric oxide synthase in gastrointestinal tract of rats |
| |
| 作者姓名： | 高瞻 朱运龙 梅琦 陈健康 黄威权 |
| |
| 作者单位： | Departments of Physiology and Histology and Embryology，Fourth Military Medical University，Xi'an710032 |
| |
| 摘 要： | Asavcrylmportant1ntracel1u1arand1ntcrccl-1ularmesscngermoleculcL1~4:,nltricoxldchasabroadspectrunlofeffectsonthcgastrointcstinaltract.Forinstance,itcandilatcbloodvcsscIs,rclaxthegastrointestinalsn1oothmuscle,promotemucussecreti0nandenl1ancethcalkalirc1cascinstomachdamage.Nitricox1dc(N())issynthcsizcdfromarglninecatalyzcdbyn1tr1cox1desynthascs(NOSs).NOSsarcgroupcdintotwobroadcate-gories,const1tutiveN()S(cN()S)thatislnvolvcdincellularsigna1andCa2 /CaMdcpcndant,andinducibleN()S(1N0S)thatt…
|
Immunohistochemical localization of nitric oxide synthase in gastrointestinal tract of rats |
| |
| Gao Zhan, Zhu Yunlong, Met Qi,Chen Jiankang, Huang Weiquan.Immunohistochemical localization of nitric oxide synthase in gastrointestinal tract of rats[J].Journal of Medical Colleges of PLA(China),1998(2). |
| |
| Authors: | Gao Zhan Zhu Yunlong Met Qi Chen Jiankang Huang Weiquan |
| |
| Abstract: | Objective: To investigate the distribution of the three subtypes of nitric oxide synthase (NOS) inthe gastrointestinal tract of rats. Methods: Immunohistochemical ABC methods were used. Results: Neuronal NOS(nNOS)-positive substance was localized in epithelial cells, endocrine cells, endothelial cells andneuronal cell bodies in the intermuscular plexus and submucous plexus. Inducible NOS(iNOS)-positive substance was located in smooth muscle cells in gastric corpus, intestinal mucosa epithelium and endocrine cells.Endothelial NOS(eNOS)-positive substance was distributed mainly in vascular endothelial cells. Conclusion:The distribution patterns of the three subtypes of NOS exhibited specificity and overlapping profile in the gastrointestinal tract of rats. |
| |
| Keywords: | nitric oxide synthase immunohistochemistry gastrointestinal tract rat |
| 本文献已被 CNKI 等数据库收录！ |
