腺瘤型原发性醛固酮增多症心脏损害的临床分析

目的研究腺瘤型原发性醛固酮增多症APA高醛固酮血症对心脏的损害,探讨临床治疗对策.方法收集156例APA和96例原发性高血压(EH)患者高血压病程、血浆醛固酮浓度、血钾浓度、肾素活性、心电图及超声心动图资料,分析心脏损害与各指标的相关性.结果APA组中150例行心电图和超声心动图检查,其中54例存在心电图异常,26例存在心动超声异常.而EH组96例中心电图异常12例,心动超声异常7例.两组比较有显著性差异.APA患者的心脏损害较为多见.结论高醛固酮血症是引起腺瘤型醛固酮增多症患者心脏损害的主要因素之一,应该引起临床重视.

Clinical analysis of cardiac damage in patients with primary hyperaldosteronism (PA) caused by adenoma

Objective To study the plasma aldosterone level and cardiac damage in aldosterone producing adenoma(APA) and to explore the approaches of clinic treatment measures. Methods The course of hypertension, the level of plasma aldosterone, the serum potassium level, the plasma renin activity, ECG and echocardiography were reviewed in 156 APA patients and 96 EH patients. The correlation between cardiac damage and each parameter were analyzed. Results The cardiac damage was freguent in aldosterone producing adenoma. Conclusions High level of plasma aldosterone is the major factor that causes heart damage. Attention should be paid to heart damage in this group of patients.