10例肺原发恶性纤维组织细胞瘤临床分析

目的研究肺原发恶性纤维组织细胞瘤的治疗方法及其预后。方法回顾性分析经手术病理证实的肺原发恶性纤维组织细胞瘤10例,其中5例单纯手术切除,3例术后放射治疗,2例术后化疗。结果10例患者中,6例生存1年以上,其中4例生存均超过2年,且3例超过3年。1年生存率为60%,2年生存率为40%。局部复发1例,远地转移1例,局部复发加远地转移3例,复发时间1～18个月。结论肺原发恶性纤维组织细胞瘤的预后较差,主要治疗手段为外科手术,术后放射治疗和化疗的疗效尚不肯定。

Clinical analysis of 10 patients with primary malignant fibrous histiocytoma of the lung

Objective Objective To study the treatment method and prognosis of primary malignant fibrous histiocytoma of the lung. Methods Ten patients with primary malignant fibrous histiocytoma of the lung proved by histopathology were reviewed retrospectively. Five were treated by surgery alone, 3 by postoperative radiotherapy and 2 by postoperative chemotherapy. Results Six of ten patients were able to survive more than 1 year. Four of the six survived more than 2 years and 3 more than 3 years. The 1 , 2 year survival rates were 60% and 40%, respectively. The relapse sites after treatment included: local recurrence (n=1); distant metastasis (n=1) and local recurrence plus distant metastasis(n=3), the interval ranging from 1 to 18 months. Conclusions The prognosis of primary malignant fibrous histiocytoma of the lung is poor. Surgery is the main treatment method. The role of either postoperative radiation therapy or chemotherapy remains unclear.