PORTAL: Pilot study on the safety and tolerance of preoperative melatonin application in patients undergoing major liver resection: a double-blind randomized placebo-controlled trial |
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| Authors: | Peter Schemmer Arash Nickkholgh Heinz Schneider Michael Sobirey Markus Weigand Moritz Koch Jürgen Weitz Markus W Büchler |
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| Affiliation: | 1.Department of General Surgery,Ruprecht-Karls University,Heidelberg,Germany;2.Department of Anesthesiology,Ruprecht-Karls University,Heidelberg,Germany;3.HealthEcon AG,Basel,Switzerland;4.Nutri~fit GmbH & Co KG,Mühlen,Germany |
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| Abstract: | Background Major surgical procedures facilitate systemic endotoxinemia and formation of free radicals with subsequent inflammatory changes that can influence the postoperative course. Experimental data suggest that preoperative supraphysiological doses of melatonin, a potent immuno-modulator and antioxidant, would decrease postoperative infectious and non-infectious complications induced by major abdominal surgery. |
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