35岁以下女性乳腺癌患者临床病理特征分析：附85例报告

目的：探讨35岁以下青年女性乳腺癌的临床病理特点。 方法：回顾性分析2005年2月—2010年11月85例35岁以下青年女性乳腺癌患者（观察组）的临床和病理资料，并与164例同期随机选取的中老年女性乳腺癌患者（对照组）资料比较。 结果：观察组85例青年乳腺癌患者的临床症状无特异性，误诊率为45.88%，平均（30.27±2.41）岁，平均病程（11.51±1.56）个月。与对照组比较，观察组肿瘤体积大、临床分期晚、组织学分级上分化差（均P<0.05），但病理类型的构成差无统计学意义（P>0.05）。此外，观察组乳腺癌组织雌激素受体（ER）、孕激素受体（PR）表达水平低于对照组，但c-erbB-2蛋白表达水平高（均P<0.05）；腋窝淋巴结转移率与淋巴结转移数多均高于对照组（均P<0.05）。 结论：青年乳腺癌具有其独特的临床、病理学和分子生物学特征，早期诊断与治疗是提高生存率的有效手段。

Clinicopathologic profiles of breast cancer in young women: a report of 85 cases

Objective: To investigate the clinicopathologic characteristics of breast cancer in women under 35 years of age. Methods: The clinical and pathological data of 85 young women (under 35 years of age) with breast cancer (observational group) admitted from 2005 to 2010 were retrospectively analyzed, and were compared with those from 164 middle-aged and elderly women with breast cancer (control group), who were admitted during the same period and randomly selected. Results: In the 85 young breast cancer women in observational group, there were no specific clinical symptoms, the misdiagnosis rate was 45.88%, average age was (30.27±2.41) years and average disease course was (11.51±1.56) months. Compared with control group, observational group showed larger tumor size, more advanced clinical stage, and poorer differentiation in histological grade (all P<0.05), but no statistical difference in constitution of the pathological types (P>0.05). In addition, the expression levels of estrogen receptor (ER) and progesterone receptor (PR) were lower but c-erbB-2 protein expression level was higher in the breast cancer tissues in observational group than those in control group (all P<0.05), and both rate and number of axillary lymph node metastasis in observational group were higher than those in control group (both P<0.05). Conclusion: Breast cancer in young women has distinct clinicopathologic characteristics and molecular biological features. Early diagnosis and treatment is the effective way to improve the survival rate in these patients.