帕罗西汀合并喹硫平治疗强迫症的效果观察

目的探讨帕罗西汀合并喹硫平治疗强迫症的临床效果和不良反应。方法将符合入组条件的60例强迫症患者随机分为研究组和对照组,每组30例,研究组服用帕罗西汀和喹硫平,对照组单用帕罗西汀,疗程均为8周。应用耶鲁-布朗强迫症状量表（Y-BOCS）、汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）于治疗前及治疗后2、4、6、8周末评定疗效,采用副反应量表（TESS）评定副反应。结果研究组治疗总有效率高于对照组,差异有统计学意义（P〈0.05）。治疗结束时两组Y-BOCS、HAMD、HAMA评分均显著下降（P〈0.05或0.01）,治疗第6周开始两组间Y-BOCS、HAMD、HAMA评分差异有统计学意义（P〈0.05）。结论帕罗西汀合并喹硫平治疗强迫症可以提高疗效,安全性较好,不会明显增加不良反应。

The effect observation of paroxetine combined with quetiapine in treat-ment of obsessive-compulsive disorder

Objective To evaluate the clinical efficiency of paroxetine combined with quetiapine in treating obsessive-compulsive disorder. Methods 60 patients with obsessive-compulsive disorder were randomly divided into study group and control group,30 cases in each group.Paroxetine and quetiapine were given to the study group,while only paroxetine was given to the control group,the treatment course were 8 weeks.Yale-Brown obsessive compulsive scale （Y-BOCS）, Hamilton depression scale （HAMD）,Hamilton anxiety scale（HAMA） were used before treatment and after 2,4,6,8 weeks treatment to assess the efficacy,treatment emergent symptom scale （TESS） was used to assess the side effects. Results The total effective rate of observation group was higher than that of control group,the difference was significant （P〈0.05）.At the end of treatment,the Y-BOCS,HAMD,HAMA score of two groups were decreased （P〈0.05 or 0.01）,while after 6 weeks treat-ment,Y-BOCS,HAMD,HAMA scores between the two groups had significant difference （P〈0.05）. Conclusion Paroxetine combined with quetiapine in treatment of obsessive-compulsive disorder can improve therapeutic efficacy,the security is better,not increase adverse reactions.