Blockade of the central effects of d-amphetamine sulfate by amantadine hydrochloride |
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| Authors: | M K Menon W G Clark R M Fleming |
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| Affiliation: | 1. Psychopharmacology Research Laboratory, Veterans Administration Hospital, Sepulveda, California 91343, USA;2. Department of Biological Chemistry, Center for Health Sciences, University of California, Los Angeles, California, U.S.A. |
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| Abstract: | Amantadine hydrochloride, unexpectedly, was found to block certain effects of d-amphetamine sulfate. In mice pretreated with amantadine, 150 mg/kg, d-amphetamine, 2 mg/kg or 5 mg/kg, failed to produce hyperactivity. This pretreatment also protected aggregated mice from the lethal effects of d-amphetamine, 30 mg/kg. Both d-amphetamine, 15 mg/kg, and chlorpromazine hydrochloride, 10 mg/kg, caused elevations in the homovanillic acid (HVA) concentrations in the caudate nucleus of mice, and amantadine pretreatment blocked this response to d-amphetamine but not that to chlorpromazine. Due to the many similarities in the pharmacological, behavioral, biochemical and clinical effects of amantadine and d-amphetamine, they may act at the same receptor and the observed antagonism may be due to a competitive blockade so that d-amphetamine fails to reach its site of action. |
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| Keywords: | Amantadine Symmetrel® Homovanillic acid (HVA) Amphetamine Dopamine Chlorpromazine |
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