Birth weight,breast cancer susceptibility loci,and breast cancer risk |
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| Authors: | Rulla M. Tamimi Pagona Lagiou Kamila Czene Jianjun Liu Anders Ekbom Chung-Cheng Hsieh Hans-Olov Adami Dimitrios Trichopoulos Per Hall |
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| Affiliation: | (1) Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA;(2) Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA;(3) Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, 75 M. Asias Street, 115 27 Athens, Greece;(4) Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden;(5) Population Genetics, Genome Institute of Singapore, Singapore, 138672, Singapore;(6) Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet/Karolinska University Hospital, 171 76 Stockholm, Sweden;(7) Division of Biostatistics and Epidemiology, UMass Cancer Center, University of Massachusetts Medical School, 364 Plantation Street, LRB 427, Worcester, MA 01605, USA; |
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| Abstract: | Background There is considerable evidence that birth weight is positively associated with breast cancer risk, and seven single-nucleotide polymorphisms (SNPs) have been conclusively associated with this risk. We have hypothesized that breast cancer susceptibility loci may have a greater influence on breast cancer risk among women with higher birth weight, who are expected to have a larger pool of mammary stem cells that are susceptible to malignant transformation. |
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