Prenatal morphine exposure alters estrogen regulation of κ receptors in the cortex and POA of adult female rats but has no effects on these receptors in adult male rats |
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| Authors: | gnes Riman czy, Romana lamberov ,Ilona Vathy |
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| Affiliation: | a Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, 1330 Morris Park Avenue, Bronx, NY 10461, USA;b Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA;c Department of Psychiatry, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Szeged, Hungary |
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| Abstract: | The binding characteristics of κ receptors were assessed in the frontal cortex (CX), striatum, hypothalamus, preoptic area (POA), cerebellum, and ventral tegmental area of adult male and female rats exposed prenatally to morphine or saline. Prenatal morphine exposure altered estrogen regulation of κ receptors in the CX and POA of females, but had no effects on κ receptors in any of the examined brain regions in male rats. |
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| Keywords: | Prenatal morphine κ Opioid receptors Estradiol |
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