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| 低相对分子质量透明质酸的制备及其促血管生成作用 | |
| 引用本文： | 王彦厚,王凤山,郭学平.低相对分子质量透明质酸的制备及其促血管生成作用[J].中国生化药物杂志,2007,28(2):107-109. |
| 作者姓名： | 王彦厚 王凤山 郭学平 |
| 作者单位： | 1. 山东大学,药学院,生化与生物技术药物研究所,山东,济南,250012;山东省淄博市药品检验所,山东,淄博,255086 2. 山东大学,药学院,生化与生物技术药物研究所,山东,济南,250012 3. 山东省生物药物研究院,山东,济南,250014 |
| 摘 要： | 目的观察2种降解方法制备的低相对分子质量(Mr)透明质酸(LMWHA)对血管生成的影响。方法采用过氧化氢氧化降解和透明质酸酶酶解的方法制备LMWHA,利用鸡胚绒毛尿囊膜(CAM)模型观察LMWHA对血管生成的影响。结果Mr不同的LMWHA,其对CAM血管生成的影响也不同;Mr低于10000的LMWHA对CAM血管生成的影响与溶剂对照组相比,差异有非常显著性意义(P<0.01)。结论Mr低于10000的LMWHA具有促进CAM血管生成的作用。 |
| 关 键 词： | 低相对分子质量透明质酸 制备 血管生成 |
| 文章编号： | 1005-1678（2007）02-0107-03 |
| 收稿时间： | 2006-06-02 |
| 修稿时间： | 2006-08-20 |
Preparation of low molecular weight hyaluronic acid and its angiogenesis effects |
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| WANG Yan-hou,WANG Feng-shan,GUO Xue-ping.Preparation of low molecular weight hyaluronic acid and its angiogenesis effects[J].Chinese Journal of Biochemical Pharmaceutics,2007,28(2):107-109. | |
| Authors: | WANG Yan-hou WANG Feng-shan GUO Xue-ping |
| Institution: | 1. Institute of Biochemical and Biotechnological Drug, School of Pharmacy, Shandong University, Jinan 250012, China ; 2. Zibo Institute for Drug Control of Shandong Province, Zibo 255086, China ; 3. Institute of Biopharmaceuticals of Shandong Province, Jinan 250014, China |
| Abstract: | Purpose To study the angiogenesis effects of low molecular weight hyaluronic acid(LMWHA) prepared by hydrogen peroxide degradation and by hyaluronidase degradation method.MethodsLMWHAs were prepar the by hydrogen peroxide degradation and by hyaluronidase degradation,the chicken chorioallantoic membrane(CAM) model was used to test the angiogenesis effects of LMWHAs.ResultsThe CAM blood vessels of LMWHAs′ groups,with Mr value lower than 10 000,increased apparently compared to that of control group(P<0.01),and the LMWHAs with different molecular weights had different effects on CAM blood vessel generation.ConclusionLMWHAs with Mr lower than 10 000 possessed angiogenesis effects. |
| Keywords: | low molecular weight hyaluronic acid preparation angiogenesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |