| 苦参碱对K562细胞增殖抑制与诱导分化的实验研究 |
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| 引用本文： | 何於娟,蒋纪恺,张彦,刘小珊,刘北忠,涂植光.苦参碱对K562细胞增殖抑制与诱导分化的实验研究[J].浙江中西医结合杂志,2001,11(4):219-221. |
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| 作者姓名： | 何於娟 蒋纪恺 张彦 刘小珊 刘北忠 涂植光 |
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| 作者单位： | 重庆医科大学临床生化研究室 重庆 400016 |
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| 基金项目： | 本课题受国家自然科学基金资助。编号：39670881 |
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| 摘 要： | 目的：观察苦参碱对K562细胞的增殖抑制和诱导分化作用。方法：以K562细胞为实验对象，采用体外培养技术，通过细胞生长曲线、细胞形态、乳酸脱氢酶（LDH）活性测定方法观察苦参碱的作用。结果：浓度为0．2－0．3mg/ml的苦参碱对K562细胞有明显的增殖抑制与诱导分化作用，实验组细胞的数量，形态和生化代谢都发生了变化。结论：这一结果将对白血病的诱导分化治疗提供有力的实验依据。
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| 关 键 词： | 苦参碱 K562细胞 细胞分化 中药 |
| 修稿时间： | 2000年11月6日 |
Experimental Study of
Sophoc arpidine on K562 Cell Proliferation Inhi bition and Inducing Differentiation |
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| He Yujuan,Jiang Jikai,Zhang Yan,et al..Experimental Study of
Sophoc arpidine on K562 Cell Proliferation Inhi bition and Inducing Differentiation[J].Zhejiang Journal of Integrated Traditional Chinese and Western Medicine,2001,11(4):219-221. |
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| Authors: | He Yujuan Jiang Jikai Zhang Yan |
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| Institution: | He Yujuan,Jiang Jikai,Zhang Yan,et al. Clinical Biochemistry Division of Chongqing Medical University.Chongqing 400016 |
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| Abstract: | To observe the effect of sophocarpidine on the proliferation inhibition and inducing differentiation to K562 cells. Methods:K562 cells were culture in vitro and observations were made on sophocarpidine by observing the cell growth curves,morphology and LDH detection. Results:Sophocarpidine at the concentration of 0.2 to 0.3mg/ml had the proliferation inhibition and inducing differentiation effects. Significant changes were observed in the cell morphology,cell numbers and biochemical metabolisms. Conclusions:The present result provided an experimental evidence to the inducing differentiation therapy of the leukemia |
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| Keywords: | K562 cells Proliferation inhibition and inducing differentiation sophocarpidine |
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