Antifungale Imidazolverbindungen I: Synthese von Derivaten des 2-Imidazolyl-1-indanols und des 2-Imidazolyl-1-tetralols mit antifungaler Wirkung

Synthesis of Derivatives of 2-Imidazolyl-1-indanol and of 2-Imidazolyl-1-tetralol with Antifungal Activity Synthesis of 2-imidazolyl-1-indanol and of 2-imidazolyl-1-tetralol and of derivatives halogenated at the benzene nucleus was accomplished from the corresponding indanones and tetralones as starting materials via the reaction of the α-bromo-ketones with imidazole and subsequent reduction with sodium borohydride. Some substituted benzoates, carbamates, and thiocarbamates as well as benzylic ethers were prepared as derivatives of these alcohols. The latter ethers were active in vitro against Candida albicans, Trichophyton rubrum, and Trichophyton mentagrohphytes.