重复经颅磁刺激联合帕利哌酮对精神分裂症患者认知功能的影响

目的 探讨重复经颅磁刺激(rTMS)联合帕利哌酮缓释片对精神分裂症患者认知功能的疗效及安全性.方法 选择符合入组条件的首发精神分裂症患者61名,随机分成治疗组30例(帕利哌酮缓释片联合rTMS),对照组31例(单纯药物).分别于治疗前及治疗4周后应用阳性与阴性症状量表(PANSS)评定临床症状;应用数字划消测验(CT)...

Effect of repetitive transcranial magnetic stimulation combined with paliperidone on cognitive function of schizophrenic patients

Obiectives To investigate the efficacy and safety of rTMS combined with palisperidone sustained release tablets for cognitive function in patients with schizophrenia.Methods 61 first episode schizophrenic patients were randomly divided into 30 cases in the treatment group(paliperidone combined with rTMS)and 31 in the control group(simple drugs).Before and after treatment for 4 weeks,PANSS was used to assess clinical symptoms.CT,WMS-RC and WCST to evaluate the patient's attention function,memory function and executive function.Results After treatment,the total score of PANSS in both groups was lower than that before treatment,and the total score of the treatment group was significantly lower than that of the control group(P<0.01).The CT and WMS-RC scores of the two groups were better than before treatment(P<0.01),the treatment group was higher than the control group(P<0.05).The WCST scores of the treatment group were better than before treatment,and the total number of responses,persistent errors,and non-persistent errors in the control group were significantly lower than before treatment(P<0.05).The number of sexual errors was significantly lower than that of the control group(P<0.05).There were no obvious side effects in both groups.Conclusion rTMS combined with paliperidone sustained-release tablets has a synergistic effect on improving the cognitive function of patients with schizophrenia and has good safety.