丁苯酞辅助治疗对老年痴呆症患者的疗效

目的 探讨丁苯酞辅助治疗对老年痴呆症患者的疗效及其可能的机制.方法 本研究对象为2018年1月～2019年8月我院收治的88例老年痴呆症患者,按照数字表法随机均分为两组,每组44人,对照组给予常规治疗,观察组在此基础上联合丁苯酞治疗.比较两组患者治疗前后病理行为评分表(BEHA VE-AD)、生活能力量表(ADL)、简...

The effect of butylphthalide in patients with senile dementia

Objective To explore the effect of butylphthalide in patients with senile dementia and its mechanism.Methods Eighty-eight patients with senile dementia in our hospital from January 2018 to August 2019 were selected and randomly divided into two groups by the number table method,44 case in each group.The control group was given conventional treatment,and the observation group was added butylphthalide.Pathological behavior score scale(BEHA VE-AD),living ability scale(ADL),simple mental status checklist(MMSE)and other scales were compared between the two groups before and after treatment.Serum amyloidβ(Aβ)level,detection of serum Glutathione peroxidase(GSH-Px),malondialdehyde(MDA),superoxide dismutase(SOD)and other oxidative stress indicators,Endothelin(ET-1),vascular endothelial growth factor(VEGF)and other indicators of vascular endothelial function were were compared between the two groups before and after treatment.Results After treatment,the ADL score and MMSE score of the two groups were significantly increased,and the serum Aβlevel and BEHA VE-AD score were significantly reduced,and the observation group was better than the control group(P<0.05).After treatment,the serum GSH-Px and SOD levels in the two groups increased,while the MDA level decreased,the observation group was better than the control group(P<0.05).After treatment,the serum ET-1 levels of the two groups were significantly reduced,and the VEGF levels were significantly increased,the observation group was better than the control group(P<0.05).Conclusion Butylphthalide adjuvant treatment can effectively improve the cognition and life ability in patients with senile dementia,which may be related to promoting the reduction of serum Aβlevel,reducing oxidative stress,and improving vascular endothelial function.