早期乳腺癌CEA mRNA阳性循环细胞检测及其临床意义

目的]研究早期乳腺癌外周血中CEAmRNA阳性循环肿瘤细胞的临床意义。方法]检测50例早期乳腺癌患者、24例乳腺良性疾病患者和20例健康志愿者外周血CEAmRNA阳性细胞。结果]早期乳腺癌患者外周血CEAmRNA阳性率为14．0％，CEAmRNA阳性率与TNM分期（P=0．004）、肿瘤大小（P=0．027）、血清CEA（P=0．000）水平异常升高显著性相关。CEAmRNA阳性患者中位无瘤生存期为18个月，与阴性患者比较差异有统计学意义（P=0．000）。结论]CEAmRNA阳性循环肿瘤细胞可能是早期乳腺癌患者监测复发转移的重要指标和独立的预后因素。

Detection of CEA mRNA-positive Circulating Tumor Cells in Patients with Early Breast Cancer and Its Clinical Sig-nificance

Purpose ] To investigate the clinical significance of CEA mRNA-positive circulating tumor cells in peripheral blood in patients with early breast cancer. Methods ] The CEA mRNA-positive circulating tumor cells in peripheral blood of 50 cases with early breast cancer, 24 cases with breast benign lesions and 20 healthy individuals were detected. Results ] The CEA mRNA positive rate in early breast cancer was 14.0%. Positive CEA mRNA significantly correlated to TNM stage （P= 0.004）, tumor size （P=0.027）, and serum CEA levels（P=0.000）. Median relapse-free time in positive CEA mRNA patients was 18 months, which was lower than that in negative CEA mRNA patients. Conclusion] CEA mRNA positive cell may be an important predictor for recurrece and metastasis in early breast cancer patients. It is an independent prognostic factor.