Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats |
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Authors: | C Ito K Onodera T Watanabe M Sato |
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Institution: | (1) Department of Psychiatry, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aobo-ku, Sendai 980-77, Japan, JP;(2) Department of Pharmacology I, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-77, Japan, JP;(3) Department of Pharmacology, Tohoku University School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-77, Japan, JP |
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Abstract: | In this study, effects of histamine (HA) agents on methamphetamine (METH)-induced stereotyped behavior and behavioral sensitization
were examined in rats. Pretreatment with a precursor of HA, L-histidine (750 mg/kg), significantly inhibited the METH (3 mg/kg)-induced stereotyped behavior, whereas pretreatment with
an inhibitor of HA synthesis, α-fluoromethylhistidine (FMH) (100 mg/kg), an H1 antagonist pyrilamine (5 mg/kg) or an H2 antagonist zolantidine (5 mg/kg) enhanced it. The inhibitory effect of L-histidine on METH-induced stereotyped behavior was significantly blocked by coadministration of pyrilamine and zolantidine,
indicating that the effect is mediated through H1 and H2 receptors. Moreover, chronic treatment with METH (3 mg/kg) significantly enhanced stereotyped behavior at the rechallenge
with METH (1 mg/kg). Chronic treatment with L-histidine (750 mg/kg) plus METH inhibited the METH-induced argumentation of stereotyped behavior, while that with FMH (100 mg/kg),
pyrilamine (5 mg/kg) or zolantidine (5 mg/kg) potentiated it. These findings suggest that the HA neuron system has an inhibitory
role in METH-induced stereotyped behavior and behavioral sensitization.
Received: 1 July 1996/Final version: 26 November 1996 |
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Keywords: | Histamine L-Histidine α -Fluoromethylhistidine Pyrilamine Zolantidine Methamphetamine Stereotyped behavior Behavioral sensitization |
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