同种异体原位肝脏移植术的临床应用研究(附9例报告)

目的总结原位全肝移植术的经验教训，以进一步提高肝移植治疗终末期肝病的效果。方法2001年3月～2006年8月，为9例终末期肝病患者实施了原位全肝移植术，其中6例为良性终末期肝病，3例为肝癌患者。前5例实施背驮式肝移植，后4例实施经典式非转流肝移植。结果1例病人存活3年以上，2例病人存活2年以上，1例病人存活1年以上，2例术后3个月，均恢复正常的工作和生活。手术后死亡病例中，1例术后1年9个月死于应用大剂量激素抗排斥反应所致的应激性溃疡大出血。2例巨大肝癌病人分别于术后27d死于肾功能衰竭、高血钾和术后56d死于脑出血。1例小肝癌病人术后出现神经并发症，术后4个月死于脑出血。结论肝移植是治疗终末期肝病的唯一有效方法。

The Clinical Application of Orthotopic Liver Transplantation (A Report of 9 Cases)

Objective Through sum up the experience and lessons of orthotopie liver transplantation,to further elvate the effectiveness of liver tran-plantation for end-stage liver disease. Methods From March 2001 to August 2006,nine eases of end-stage liver disease patients received orthotopic liver transsplantation, six cases were benign end-stage liver disease,3 cases were liver carcinoma.The first five cases operation were piggyback liver transplantation,the last four cases were classical bypass livr transplantation. Results The post - operation sup, ied patient, one patient survied more than 3 5ears,2 paticut surcivad more than 2 years, one patient surxixed tot more than one year, tw cases only three months, all of them resume their normal work and life. Patients died after surgery, one patient died one year and nine moeths due to stress ulcer bleeding followed by large doses hormone to anti-rejection response ,two cases of large hepatoeellular carcinoma patients, one died of kidney failure and hyperkalemia after 27 days, another dird of abrain lmremorrhage after 56 days,one cases of small helmtocellular carcinoma patient with neurological complieations, died of eerebral hemoradags after four months. Conclusion Liver transplantation is the only effective way to treat the end-stage liver disease.