| 血清YKL-40在诊断子宫内膜癌中的价值初探 |
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| 引用本文： | 司晓辉,范江涛,廖雁,耿晓丽,谢青丽. 血清YKL-40在诊断子宫内膜癌中的价值初探[J]. 实用妇产科杂志, 2011, 27(2) |
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| 作者姓名： | 司晓辉 范江涛 廖雁 耿晓丽 谢青丽 |
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| 作者单位： | 广西医科大学第一附属医院,广西,南宁,530021 |
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| 基金项目： | 广西青年科学基金(项目编号:0832034) |
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| 摘 要： | 目的:探讨血清甲壳质酶蛋白40(YKL-40)在子宫内膜癌诊断和疗效、预后评价的价值。方法:用酶联免疫吸附法(ELISA)测定子宫内膜癌患者33例,子宫肌瘤患者27例及30例健康妇女血清中的YKL-40水平,比较血清YKL-40在3组间的差异,以及22例子宫内膜癌患者手术治疗前后该指标的变化。结果:子宫内膜癌组血清YKL-40水平显著高于子宫肌瘤组(P=0.001)和健康组(P=0.001),而子宫肌瘤组和健康组之间差异无统计学意义(P=0.661)。22例子宫内膜癌患者术后7天血清YKL-40水平显著低于术前水平(P=0.000);健康组与子宫内膜癌组评估YKL-40用于诊断子宫内膜癌的ROC曲线下面积为0.830,子宫肌瘤组与子宫内膜癌组评估YKL-40用于诊断子宫内膜癌的ROC曲线下面积为0.773。以血清YKL-40129.97μg/L为临界值时,其诊断子宫内膜癌的敏感性和特异性分别为75.8%和80.0%,阳性似然比为3.59,阴性似然比为0.31,准确度为77.8%,阳性预测值为67.6%,阴性预测值为85.0%。结论:血清YKL-40水平检测在子宫内膜癌的诊断,疗效和预后评价方面均有一定的临床价...
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| 关 键 词： | 血清甲壳质酶蛋白40 子宫内膜癌 肿瘤标志物 |
Preliminary Research of Serum YKL-40 in the Diagnosis of Endometrail Carcinoma |
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| SI Xiaohui,FAN Jiangtao,LIAO Yan,et al. Preliminary Research of Serum YKL-40 in the Diagnosis of Endometrail Carcinoma[J]. Journal of Practical Obstetrics and Gynecology, 2011, 27(2) |
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| Authors: | SI Xiaohui FAN Jiangtao LIAO Yan et al |
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| Affiliation: | SI Xiaohui,FAN Jiangtao,LIAO Yan,et al(The First Affiliated Hospital of Guangxi Medical University,Nanning Guangxi 530021,China) |
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| Abstract: | Objectives:To Explore the value of serum YKL-40 in the diagnosis,therapeutic effects and prognostic evaluation of endometrial carcinoma. Methods:Enzyme-linked immuunosorbent assay(ELISA) was used to measure serum levels of YKL-40 in 33 cases of endometrial carcinoma,27cases of uterine myoma,and 30 cases of healthy women. The differences of serum YKL-40 levels among the three groups were compared. The changes of YKL-40 before and after operation also compared in 22 cases of endometrial carcinoma. Results:Ser... |
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| Keywords: | YKL-40 Endometrial carcinoma Tumor marker |
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