| 宫颈鳞癌中膜突蛋白及CD105的表达及其临床意义 |
| |
| 引用本文： | 周勤,邓婷. 宫颈鳞癌中膜突蛋白及CD105的表达及其临床意义[J]. 实用妇产科杂志, 2011, 27(2) |
| |
| 作者姓名： | 周勤 邓婷 |
| |
| 作者单位： | 重庆医科大学附属第一医院,重庆,400016 |
| |
| 摘 要： | 目的:研究膜突蛋白(Moesin)及CD105在各级宫颈病变中的表达水平,探讨其与宫颈鳞癌的发展及浸润的关系。方法:采用免疫组化SP法检测31例正常宫颈组织(NCE)、48例宫颈上皮内瘤样变(CIN)及66例宫颈鳞癌组织(SCC)中Moesin及CD105的表达。结果:从NCE到CIN到SCC组,Moesin的表达水平显著升高。在CIN组Moesin的表达随病变程度加重而升高;SCC组中与FIGO分期、浸润深度、盆腔淋巴转移有关,与组织分化程度及年龄无关。从NCE到CIN到SCC组,CD105表达的微血管密度(MVD)值显著升高,在SCC组中与淋巴转移及浸润深度有关,且与Moesin蛋白具有较高关联性。结论:Moesin蛋白及CD105可能在宫颈鳞癌的发展及转移过程中起重要作用,二者结合可能成为判断宫颈病变生物学行为的重要指标。
|
| 关 键 词： | 宫颈肿瘤 膜突蛋白 CD105 免疫组织化学 |
Expression of Moesin and Endoglin(CD 105)in Squamous Cervical Carcinoma and Its Clinic Significance |
| |
| ZHOU Qin,DENG Ting. Expression of Moesin and Endoglin(CD 105)in Squamous Cervical Carcinoma and Its Clinic Significance[J]. Journal of Practical Obstetrics and Gynecology, 2011, 27(2) |
| |
| Authors: | ZHOU Qin DENG Ting |
| |
| Affiliation: | ZHOU Qin,DENG Ting(The First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China) |
| |
| Abstract: | Objective:To study the expression of moesin and CD105 in different grade of cervical cancer and explore its relationship with invasion and metastasis of squamous cervical carcinoma. Methods:The expression of Moesin and microvascular density (MVD ) labeled by CD105 in 31 cases of normal cervical epithelium (NCE),48 cases of cervical intraepithelial neoplasia (CIN ) and 66 cases of squamous carcinoma of cervix(SCC) were detected by immunohistochemistry SP method.Results:The positive expression of Moesin was r... |
| |
| Keywords: | Cervical carcinoma Moesin CD105 Immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
